Targeting glycolysis in proliferative kidney diseases

Hypereosinophilic syndrome and proliferative diseases.

Therapy principles of the last decade and recent advances in the research of polynuclear eosinophil have led to a new approach in the hypereosinophilic syndrome (HES), with important consequences on the development of new and effective therapies. HES is defined by persistent and marked eosinophilia and eosinophil-related organ damage in the absence of any evident cause of hypereosinophilia. Two...

Proliferative Kidney Disease in Salmonid Fishes

Neurologic manifestations in children and adolescents with chronic kidney diseases

Background and Objective: Chronic renal failure (CRF) may have many effects on nervous system and manifest as headache, seizure, dialysis disequilibrium syndrome, cerebral hemorrhage, hypertensive encephalopathy, uremic neuropathy, and some neurologic complications of transplantation. In this present study we investigate neurologic disorders in children with CRF. Methods: In this descriptive...

Kidney Diseases in Diabetes

The primary constituent of urinary protein in diabetic nephropathy is albumin. Consequently, quantification of urinary albumin excretion is central to any description of diabetic renal disease. Albumin excretion can be determined from timed urine collections, and 24hour, overnight, or even shorter collection periods are used. Measurement of the urinary albumin-to-creatinine ratio in untimed uri...

miR‐148b inhibits glycolysis in gastric cancer through targeting SLC2A1

Although the molecular biology of GC has been well characterized, early diagnostic biomarkers and effective therapeutic options in gastric cancer are still under investigation. Here, we found that miR-148b expression decreased in human gastric cancer tissues compared with matched adjacent nontumor tissues by q-PCR analysis and in situ hybridization. Further investigation revealed that overexpre...